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<p><span>Estrogenic effect of </span><em>Erythrina variegata</em><span> L. in prepubertal female rats</span></p>

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Title Statement <p><span>Estrogenic effect of </span><em>Erythrina variegata</em><span> L. in prepubertal female rats</span></p>
 
Added Entry - Uncontrolled Name Mangathayaru, K ; Sri Ramachandra University
Sarah, K ; Department of Pathology Sri Ramachandra Medical College and Research Institute Porur, Chennai - 600116 Tamilnadu
Balakrishna, K ; Captain Srinivasamurty Drug Research Institutue for Ayurveda and Siddha (CSMDRIAS) Ministry of Health and Family Welfare, Government of India Arumbakkam, Chennai 600 106 Tamilnadu
 
Uncontrolled Index Term medicinal plant utilization; phytopharmacology; traditional medicine
β-sitosterol, Daucosterol, Erythrina variegata, Estrogenic activity, Fabaceae, Oleanolic acid
 
Summary, etc. <table class="itemDisplayTable"><tbody><tr><td class="metadataFieldValue">Alcoholic extract of <em>Erythrina variegata </em>L. leaves was evaluated by uterotrophic assay in 17 day old prepubertal female rats and was chromatographically processed for compound isolation. The animals divided into 3 (n=6) groups were treated for 7 days as follows: Control group (Grp I) –vehicle, 0.5% Na CMC, 5 mL/kg bw p.o, <em>E. variegata</em> alcohol extract group (Grp II) – 250 mg/kg bw/day in vehicle p.o., Ethinyl estradiol group (Grp III) - 30μg/kg bw/day in vehicle, p.o. 24 h post last exposure to extract. Animals were sacrificed and the uterus and ovaries examined for classical morphological and histomorphometric changes induced by estrogen stimulation. Extract treatment increased the absolute and normalized uterine weight, uterine diameter, endometrial thickness, luminal epithelial cell height, diameter of ovary and the number of primary and secondary ovarian follicles relative to vehicle control. Presence of ciliated epithelial cells in the oviduct and signs of vascularization in the cortex of ovarian sections in this group similar to EEG is indicative of estrogenic activity of the tested extract. This is consequent to the antioxidant activity of β-sitosterol, daucosterol and oleanolic isolated from the extract. This study supports the earlier reported hypolipidaemic and anti-atherosclerotic activities, lending scientific validity to anti-obesity claims in traditional medicine.</td></tr><tr><td class="metadataFieldLabel"><br /></td><td class="metadataFieldValue"><br /></td></tr></tbody></table>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-02-19 08:35:30
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/4189
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 5, ##issue.no## 3 (2014): September 2014
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/4189/8703
http://op.niscair.res.in/index.php/IJNPR/article/download/4189/8704
 
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