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In vitro antimicrobial activity of essential oils and their acetylenic constituents

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Title Statement In vitro antimicrobial activity of essential oils and their acetylenic constituents
 
Added Entry - Uncontrolled Name Kumar, Vinod ; Kumaun University
Mathela, CS ; Department of Chemistry, Kumaun University Nainital 263 001, Uttarakhand, India
Tewari, Geeta ; Department of Chemistry, Kumaun University Nainital 263 001, Uttarakhand, India
Panwar, Amit ; Deapartment of Biotechnology, Bhimtal, Kumaun University Nainital 263 001, Uttarakhand, India
Pandey, Veena ; Deapartment of Biotechnology, Bhimtal, Kumaun University Nainital 263 001, Uttarakhand, India
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Uncontrolled Index Term Asteraceae, Antibacterial activity, Essential oils, (Z)-lachnophyllum ester, 2(E);8(Z)-matricaria ester
 
Summary, etc. The emergence of new infections and increase of bacterial drug resistance has prompted interest for the development of new antibacterial agents from natural sources.This study is an attempt to assess the therapeutic potential of plant constituents as new antimicrobial drugs. The essential oils from six Asteraceae species belonging to the genus <em>Erigeron</em>, <em>Aster</em>, and <em>Senecio</em> were evaluated for their antibacterial activity against six bacteria namely <em>Pseudomonas </em>aeruginosa<em>, Bacillus subtilis, Escherichia coli, Aeromonas </em>hydrophilla<em>, Klebsiella pneumonia</em>, and <em>Streptomyces candidus </em> using agar well diffusion method. The results revealed (Z)-lachnophyllum (&lt;68 %) and 2(E), 8(Z)-matricaria esters (&lt;62 %) as the major acetylenic constituents in four <em>Erigeron</em> species. <em>E. mucronatus</em> showed the highest activity against Gram-positive bacteria <em>S. candidus</em> (8.3 mm, MIC 5 µL/mL) and <em>B. subtilis</em> (11.0 mm, MIC 10 µL/mL). (Z)-Lachnophyllum and 2(E), 8(Z)-matricaria esters showed maximum activity against <em>S. candidus</em> (MICs 5 µL/mL). The results showed that the oils containing acetylenic constituents have potential as natural agents for treatment of infections caused by these bacteria.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-06-02 15:25:38
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/14114
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 1 (2017): March 2017
 
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