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Protective effect of ethanolic extract of <em>Psidium guajava</em> L. leaves in tacrine-induced orofacial dyskinesia by assessing its neurobehavioral and biochemical alterations in rats

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Title Statement Protective effect of ethanolic extract of <em>Psidium guajava</em> L. leaves in tacrine-induced orofacial dyskinesia by assessing its neurobehavioral and biochemical alterations in rats
 
Added Entry - Uncontrolled Name Mohan, Mahalaxmi ; Mahatma Gandhi Vidyamandir's Pharmacy College Mumbai Agra Road, Panchavati, Nasik-422003
Chintala, Saritha
Yarlagadda, Sanjyothi
 
Uncontrolled Index Term herbal pharmacology
Orofacial dyskinesia, Psidium guajava L., Tacrine, Vacuous chewing movement.
 
Summary, etc. The present study investigated the protective effect of the ethanolic extract of <em>Psidium guajava</em> L. against tacrine-induced orofacial dyskinesia in rats. Behavioral assessments such as vacuous chewing movements, tongue protrusions, orofacial bursts, locomotion, and cognition were recorded. Forebrain of tacrine treated animals was assessed for its antioxidant levels. <em>P. guajava </em> (100 and 200 mg/kg, p.o.) significantly (P &lt;0.05) inhibited tacrine induced vacuous chewing movements, tongue protrusions, orofacial bursts and significantly (P &lt;0.05) increased locomotion and cognition. Treatment with <em>P. </em><em>guajava</em> (100 and 200 mg/kg, p.o.) exhibited significant elevation in the levels of superoxide dismutase, catalase, glutathione reductase and inhibition of lipid peroxidation in the forebrain region as compared to the tacrine treated group of animals. Results suggest that P. <em>guajava</em> extract (100 and 200 mg/kg) has good potential to ameliorate tacrine induced orofacial dyskinesia.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-04-12 09:57:06
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/10725
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 4 (2016): December 2016
 
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