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A STUDY ON AMELIORATING EFFECT OF CAESALPINIA SAPPAN L IN LEAD INDUCED OXIDATIVE STRESS IN RATS

KrishiKosh

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Title A STUDY ON AMELIORATING EFFECT OF CAESALPINIA SAPPAN L IN LEAD INDUCED OXIDATIVE STRESS IN RATS
MVSC;CVSc;TPTY; Acc No: T1368
 
Creator HEMALATHA, K
 
Contributor ESWARA PRASAD, P (Major)
PADMAJA, K
ADILAXMAMMA, K
SREENIVASULU, D
 
Subject RATS ; AMELIORATING EFFECT; CAESALPINIA SAPPAN; lead toxicity; OXIDATIVE STRESS
 
Description THESES
ABSTRACT :
An experiment was conducted to study the ameliorating effect of Caesalpinia sappan in lead toxicity using a total of 24 male wistar rats which were randomly divided into four groups consisting of six animals in each group. Group I was maintained on basal diet as control and group II on lead acetate @ 90 mg/kg orally along with basal diet as toxic control group. Group III was maintained on methanolic extract of Caesalpinia sappan stem bark @ 100 mg/kg along with the basal diet and group IV on lead acetate @ 90 mg/ kg and methanolic extract of Caesalpinia sappan @ 100mg/ kg along with the basal diet for 28 days.
The serum biomarkers were estimated for assessing the damage caused to liver, kidney and heart due to lead toxicity. Parameters like total protein, ALT, troponins, AST, creatinine and BUN values were measured on Day 14 and Day 28 from freshly collected blood samples. Tissue samples were collected and preserved at -20ᵒC for analysis of tissue antioxidant profile (TBARS, glutathione, GST, SOD, catalase, membrane ATPases, Vitamin E and C) and lead content. Blood samples were collected and haematological parameters (RBC, WBC, Hb and PCV) were estimated at the end of 28th day of experiment.
The results indicated that lead toxic group (group II) showed a significant (p
DEPARTMENT OF VETERINARY BIOCHEMISTRY ,
COLLEGE OF VETERINARY SCIENCE,
SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI – 517 502. (A.P.) INDIA
 
Date 2016-12-27T12:46:50Z
2016-12-27T12:46:50Z
2010-09
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/93199
 
Language en
 
Format application/pdf
 
Publisher Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P