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Studies on genotoxicity and immunotoxicity of acetamiprid - a pyridyl methylamine neonicotinoid insecticide in mice

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Title Studies on genotoxicity and immunotoxicity of acetamiprid - a pyridyl methylamine neonicotinoid insecticide in mice
 
Creator Preeti
 
Contributor Jain, S. K.
 
Subject Acetamiprid, Genotoxicity, Micronucleus test (MNT), Chromosomal aberration studies (CAs), Immunotoxicity, Hemagglutination test (HA titre), Delayed type hypersensitivity test (DTH)
 
Description Acetamiprid is widely and most commonly used insecticide used to control the pests in crops,
vegetables and fruits and also to protect the domestic animals against the wide range of parasites; yet
its genotoxic and immunotoxic effects have not been studied extensively. Therefore investigation was
carried out to assess the genotoxic and immunotoxic effects of acetamiprid in Swiss albino male mice.
Two dose levels of acetamiprid (4.6 and 2.3 mg/kg/day) along with 3% gum acacia as negative control
were administered to mice daily for 30, 60 and 90 days and subsequent genotoxic and immunotoxic
effects were assayed by MNT, CAs, HA and DTH. The MNT revealed significant difference in PCE
with MN, and total MN cells (PCEs+ NCEs) in 90 days treatment group at higher dose level. The P/N
ratio was significantly decreased at higher dose level after exposure for all three treatment periods. In
CAs, a significant difference was observed in various types of chromosomal aberrations at higher dose
level in 60 and 90 days time period. Exposure of acetamiprid @ 4.6 mg/kg b.wt for 60 days and 2.3 and
4.6 mg/kg b.wt for 30 and 90 days caused significant decrease in HA titer. Acetamiprid induced
significant decrease in DTH response at higher dose level for 30 and 60 days and at both dose level
exposure for 90 days. Higher dose level of acetamiprid for 90 days treatment time caused significant
decrease in Hb, MCV and MCH and for 60 and 90 days treated time caused significant difference in
MCHC and TLC. Acetamiprid produced toxicity in blood parameters when administered for 90 days.
Histopathology of liver, kidney and testis revealed increased severity of degenerative changes with
increase in dose level and treatment time. The results indicated that acetamiprid is a weak mutagen
when exposed @ 4.6 mg/kg b.wt. for 90 days and immunosuppressant as it suppressed both humoral
and cell mediated immune response at all treatment periods (30, 60 and 90 days) in mice.
 
Date 2016-08-17T11:48:13Z
2016-08-17T11:48:13Z
2015
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/72716
 
Language en
 
Format application/pdf
 
Publisher LUVAS