Record Details

Evaluation of Phytochemical compounds from Carica papaya as Potential drugs against Dengue virus: An In silico approach

KrishiKosh

View Archive Info
 
 
Field Value
 
Title Evaluation of Phytochemical compounds from Carica papaya as Potential drugs against Dengue virus: An In silico approach
Evaluation of Phytochemical compounds from Carica papaya as Potential drugs against Dengue virus: An In silico approach
 
Creator Mishra, Parinita
 
Contributor Rath, S N
 
Subject toxicity, proteins, acidity, biological phenomena, diseases, aromatic compounds, enzymes, organic acids, carbohydrates, papayas
 
Description Dengue fever is a globally important arboviral infection transmitted by mosquitoes
which is an issue of serious concern for the interest of mankind. Dengue virus (DENV)
infection is an important arthropod-borne viral infection infecting about 2.5 billion people
worldwide. Dengue virus is also known as flavivirus, a member of Flaviviridae family. It is a
positive–stranded RNA virus of 11 kb RNA genome encoding for a single polyprotein with
three structural and seven non-structural viral proteins. Existing reports states 5 distinct
serotypes of dengue virus (DENV-1, DENV-2, DENV-3, DENV-4 and DENV-5). All the
serotypes of dengue virus are transmitted from one host to the other by mosquitoes, primarily
Aedes aegypti and Aedes albopictus. In the present study an Insilico approach was undertaken
to report the antiviral (dengue) activity of 56 phytochemical compounds from the leaf extract
of Carica papaya commonly prescribed for the dengue patients against five potential dengue
targets NS1, NS2B-NS3 Protease, NS3 Helicase, NS5 and Glycoprotein E in comparison to
the docking studies with existing eight anti viral (dengue) drugs. The molecular docking and
insilico approach represented better results of phytochemical compounds than anti viral
drugs. Docking scores of phytochemical compounds reflected the binding affinity of saponin
against NS1 as -13.49kcal/mol, binding affinity of Stigmast-5-en-3-ol, 1-Sitosterol and 9-cis-
Violaxanthin against NS2BNS3 Protease as -12.27kcal/mol, -12.18kcal/mol and -
10.44kcal/mol, binding affinity of saponin against NS3 Helicase as -14.12kcal/mol, binding
affinity of saponin against NS5 as -16.36kcal/mol, binding affinity of Flavanone,
Dicoumarol, Terpin and 9-cis-Violaxanthin against GlycoproteinE as -9.62 kcal/mol,-11.19
kcal/mol,-9.55 kcal/mol and -9.5 kcal/mol respectively. Out of screened 56 phytochemical
compounds Flavanone, Dicoumarol and Terpin were inferred as the best compounds based on
their binding affinity, druglikeliness, ADMET property, toxicity and bioactivity. Hence,
based upon our results we would like to suggest for further analysis of these phytochemical
compounds to confirm their efficacy and to evaluate their anti viral drug potency.
 
Date 2017-01-03T12:28:55Z
2017-01-03T12:28:55Z
2016
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/94129
 
Language en
 
Relation Th;4618
 
Format application/pdf