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Sequential Pathology of Experimental Infectious Bursal Disease in Chicken

KrishiKosh

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Title Sequential Pathology of Experimental Infectious Bursal Disease in Chicken
IJVP_29(2)_85-87_2005
 
Creator Hemalatha, S.
Manohar, B. Murali
Balachandran, C.
 
Subject Infectious bursal disease
Lymphoid organs
Pathology
 
Description One hundred five weeks old, male specific antibody negative (SAN) chickens were infected with 1000 CID50 of infectious bursal disease virus both intracloacally and intraocularly to study the sequential pathological changes. Mortality started from 48 hours post infection (HPI) (10 per cent), peaked at 72 HPI (66.66 per cent) and then declined gradually. Grossly, haemorrhages on the thighs, breast and proventriculus-gizzard junction were noticed. Odema of bursa followed by atrophy of thymus and bursa were noticed. Bursal lesions started as early as 1-3 HPI with mild lymphoid depletion and necrosis in the cortex and vacuolar changes in the plical
epithelium. The severity of the lesions increased with involvement of the cortex initially and later extended into the medulla and interfollicular connective tissue. Inter and intrafollicular odema was very prominent with cysts containing eosinophilic debris in the medulla, moderate infiltration of heterophils in the intra and interfollicular spaces from 48 to 96 HPI. In addition to the above changes, stray apoptotic bodies in a few plical cells at 120 HPI were seen. Glandular transformation of all follicles at 14 days post infection (DPI) and regeneration of cortical lymphocytes at 28 DPI were observed. Atrophic thymus, diffuse lymphoid depletion and reticulum cell
hyperplasia in spleen, plasma cell depletion in Harderian gland and diffuse lymphoid necrosis and heterophil infiltration in germinal centers of caecal tonsils were observed. Hypertrophy of Kupffer cells, mild vacuolar degenerative changes in hepatocytes and focal mononuclear cell infiltration in liver, interstitial mononuclear cell infiltration in kidneys and degenerative changes in proventricular glandular epithelium were evidence in the infection.
 
Date 2016-07-22T15:54:42Z
2016-07-22T15:54:42Z
2005
 
Type Article
 
Identifier http://krishikosh.egranth.ac.in/handle/1/69420
 
Language en
 
Format application/pdf
 
Publisher Indian Journal of Veterinary Pathology