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Study On The Comparative Efficacy Of Diagnostic Tests In The Early Diagnosis Of Canine Liver Diseases

KrishiKosh

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Title Study On The Comparative Efficacy Of Diagnostic Tests In The Early Diagnosis Of Canine Liver Diseases
 
Creator Sumathi, D
 
Contributor Prathaban, S
 
Subject Canines
liver diseases
Ultrasonography
Diagnosis
 
Description The early diagnosis of liver disease remains a major challenge for the
veterinary practitioners. In this back drop, a study entitled “Study on the
comparative efficacy of diagnostic tests in the early diagnosis of canine liver
diseases” was planned and conducted with the objectives of evaluating the
incidence,
etiological
pattern,
clinico-pathological
and ultrasonographic
changes of canine liver diseases. The study consisted of 6 healthy dogs
acting as controls and 100 cases of various liver diseases, which were divided
into three groups viz. parenchymal disorders, biliary disorders and neoplastic
disorders. The parameters studied consisted of incidence analysis, medical
history, clinical and physical examination findings, hemato-biochemical
parameters (Hemoglobin, Total erythrocyte count, PCV, MCV, MCH, MCHC,
Total leucocyte count, Differential count, Cholesterol, ALP, ALT, AST,
GGT,BUN, Creatinine, Glucose, Total protein, Albumin, Total Bilirubin, Direct
bilirubin), Coagulation parameters (Platelet, PT and aPTT), Ultrasonography,
cytology and histopathological findings .
The incidence of canine liver diseases was 0.15 per cent of total
number of medical cases attended and 0.43 per cent of the gastrointestinal
case loads of the Madras Veterinary College Teaching Hospital. The mostcommon liver disease was that of parenchymal disorders with 73 percent
incidence (73/100), followed by biliary disorders 18 per cent (18/100) and
neoplastic disorder 9 per cent (9/100). Non-descript dogs dominated the
incidence in all the groups of liver diseases followed by Spitz in both
neoplastic disorders and parenchymal disorders.In case of biliary disorders
German shepherd followed the Non descript dogs in the incidence levels.
Dogs aged above four years were most commonly affected and males
dominated the incidence in all groups of liver diseases.
Common clinical signs observed in biliary disorders were vomiting
followed by anorexia / decreased appetite and weight loss, jaundice and
abdominal pain. The commonly observed clinical signs in neoplastic disorders
were weakness and anaemia (Tachycardia/Tachypnoea) followed by anorexia
/ reduced appetite, palpably distended liver (Hepatomegaly), poor hair coat,
vomiting, weight loss and ascites. The commonly observed clinical signs in
parenchymal disorders were anorexia / reduced appetite followed by weight
loss, vomiting, palpably distended liver (hepatomegaly), ascites, diarrhoea
and abdominal pain.
Clinico-pathological
changes
such
as
erythrogram
revealed
a
significant anaemia in all the three groups. Leucocytosis with neutrophilia was
observed in all the three groups. Similarly a significant reduction in total
protein and allbumin levels was found to be consistent in all the three groups.
The total bilirubin and direct bilirubin was significantly elevated in biliary
disorders group.Though the elevation in liver enzyme activities was evident
they were statistically non significant. Due to these limitations, ultrasound
imaging was deployed and the same was found to have better diagnostic
yield. Histopathology formed the gold standard in classification of type of liver
dieases. 3D ultrasonography studies helped in better visualisation of lesions
in liver diseases.
 
Date 2016-05-17T14:05:38Z
2016-05-17T14:05:38Z
2012
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/66028
 
Language en
 
Format application/pdf
 
Publisher Tamil Nadu Veterinary and Animal Sciences University