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Evaluation of Tumor Induced Angiogenesis in Rat and Canine Mammary Gland Tumors.

KrishiKosh

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Title Evaluation of Tumor Induced Angiogenesis in Rat and Canine Mammary Gland Tumors.
 
Creator Mohankumar Shettar
 
Contributor Suguna Rao
Ananda Kumar, A.
Satyanarayana, M.L.
Byregowda, S.M.
Suryanarayana, V.V.S.
Ramachandra, S.G.
Shridhar, N.B.
 
Subject DMBA, Angiogenesis, RT PCR, Immunohistochemistry
 
Description Ph.D. Thesis
Angiogenesis is a vital process essential for tumour growth, invasion and
metastasis and is regulated by many factors of which, VEGF and MMP2 are the most
important ones. The present study was carried out to evaluate tumour induced
angiogenesis in spontaneous canine and induced rat mammary tumours, based on
immunohistochemical and real time PCR expression of VEGF and MMP2. In rats,
tumours were induced by oral administration of DMBA. The most common histological
type of mammary tumour encountered in canine and rats was papillary adenocarcinoma.
The expression of VEGF and MMP2 was observed by both immunohistochemical
and PCR methods in all the tumour types of both canine and rat mammary tumours. The
expression was higher in malignant tumours compared to benign and non-neoplastic
growths. Among malignant tumours the expression of VEGF and MMP2 varied between
the tumour types. In canine mammary tumours the expression of VEGF was highest in
papillary adenocarcinoma complex type and MMP2 in papillary adenocarcinoma and
adenosquamous carcinoma. In rat mammary tumours the VEGF and MMP2 expressions
were highest in papillary adenocarcinoma. The results suggested that a higher angiogenic
process occurred in malignant types, which correlated, with increased microvasculatures
in histological preparations.
Comparison of tumour induced angiogenesis between canine and rat mammary
tumours indicated that the process of angiogenesis did not vary between them and VEGF
and MMP2 occurred as independent factors.
 
Date 2016-08-02T13:55:21Z
2016-08-02T13:55:21Z
2012-04-17
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/70556
 
Language en
 
Format application/pdf
 
Publisher Karnataka Veterinary, Animal and Fisheries Sciences University, Bidar