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Study of Apoptosis in the Sublethal Dose of Penicillic Acid Toxicity in Broiler Chickens
KrishiKosh
View Archive Info| Field | Value | |
| Title |
Study of Apoptosis in the Sublethal Dose of Penicillic Acid Toxicity in Broiler Chickens
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| Creator |
Pazhanivel, N.
Balachandran, C. Manohar, B. Murali Raj, G. Dhinakar Balakrishnan, V. Raja, A. |
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| Subject |
Broiler Chicken
Penicillic Acid Toxicity Apoptosis |
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| Description |
Penicillic acid (PA), a mycotoxin, was originally isolated from the cultures of Penicillium puberulum. The present study was undertaken to study the apoptosis in the sublethal dose of penicillic acid mycotoxicosis in broiler chicken. Eighteen day-old broiler chicks were fed with control diet for the period of three weeks. Subsequently, the birds were randomly distributed to two groups of nine birds each and fed with control and 15 ppm of penicillic toxin diets. Three birds from control and treated groups were sacrificed at c24, 48 and 72 h after treatment in the acute toxicity trial. Similarly, six birds (3 control and 3 penicillic acid - 15 ppm) were used for subacute toxicity trial (21 days) and sacrificed to study the apoptosis in the spleen and thymus by using flow cytometric analysis with the Annexin V kit to assess apoptosis and necrosis in splenocytes and thymocytes. This research indicated that peak induction of apoptosis was observed at 24 h treatment of penicillic acid (15 ppm).
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| Date |
2016-08-09T10:51:44Z
2016-08-09T10:51:44Z 2014-07 |
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| Type |
Article
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| Identifier |
http://krishikosh.egranth.ac.in/handle/1/71676
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| Language |
en
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| Format |
application/pdf
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| Publisher |
International Journal of Life Science & Pharma Research
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