Efficacy Of Growth Factor Supplemented Fish (Catla Catla) Collagen For Augmenting Wound Healing In Cattle
KrishiKosh
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Title |
Efficacy Of Growth Factor Supplemented Fish (Catla Catla) Collagen For Augmenting Wound Healing In Cattle
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Creator |
Devaraj, C.
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Contributor |
Leela, V.
Loganathasamy, K. Ramesh, Geetha William, B. Justin |
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Subject |
Cattle
Collagen films Wound healing Growth factors |
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Description |
Collagen based biomaterials have been widely used in tissue engineering and regenerative medicine. Growth factors are potential mediators of wound healing and have also been used in clinical trial for accelerating tissue repair. In order to study the efficacy of collagen film and growth factor enriched collagen film in wound healing in cattle, fish scales were collected from local market, processed and collagen was extracted and cast into a film. The dried collagen films were enriched with fibroblast growth factor (10μg/cm2), epidermal growth factor (10μg/cm2) and vascular endothelial growth factor (5μg/cm2) and were sterilized using ethylene oxide. The present study was conducted in sixty clinical cases of open wounds in cattle presented to the Large Animal Outpatient Unit of Madras Veterinary College Teaching Hospital. The animals were randomly selected and divided into ten groups of six animals each. The wounds were treated with antibiotic control, collagen film, collagen films enriched with EGF, FGF and VEGF. Clinical observations, wound planimetry (percentage of epithelialization, percentage of wound contraction and percentage of wound healing), haematological evaluation (RBC, Hb, PCV, WBC, DC and platelet count), serum biochemical analysis (glucose, total protein, ALP and acid phosphatase), heat shock protein 47 expression and histopathological evaluation were done in all the groups on day 0, 7 and 14.. The percentage of wound re-epithelialisation, wound contraction and wound healing were significantly (p |
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Date |
2016-05-24T16:58:06Z
2016-05-24T16:58:06Z 2014 |
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Type |
Thesis
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Identifier |
http://krishikosh.egranth.ac.in/handle/1/66288
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Language |
en
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Format |
application/pdf
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Publisher |
Tamil Nadu Veterinary and Animal Sciences University
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