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Efficacy Of Growth Factor Supplemented Fish (Catla Catla) Collagen For Augmenting Wound Healing In Cattle

KrishiKosh

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Title Efficacy Of Growth Factor Supplemented Fish (Catla Catla) Collagen For Augmenting Wound Healing In Cattle
 
Creator Devaraj, C.
 
Contributor Leela, V.
Loganathasamy, K.
Ramesh, Geetha
William, B. Justin
 
Subject Cattle
Collagen films
Wound healing
Growth factors
 
Description Collagen based biomaterials have been widely used in tissue engineering and
regenerative medicine. Growth factors are potential mediators of wound healing and
have also been used in clinical trial for accelerating tissue repair. In order to study the
efficacy of collagen film and growth factor enriched collagen film in wound healing
in cattle, fish scales were collected from local market, processed and collagen was
extracted and cast into a film. The dried collagen films were enriched with fibroblast
growth factor (10μg/cm2), epidermal growth factor (10μg/cm2) and vascular
endothelial growth factor (5μg/cm2) and were sterilized using ethylene oxide.
The present study was conducted in sixty clinical cases of open wounds in
cattle presented to the Large Animal Outpatient Unit of Madras Veterinary College
Teaching Hospital. The animals were randomly selected and divided into ten groups
of six animals each. The wounds were treated with antibiotic control, collagen film,
collagen films enriched with EGF, FGF and VEGF. Clinical observations, wound
planimetry (percentage of epithelialization, percentage of wound contraction and
percentage of wound healing), haematological evaluation (RBC, Hb, PCV, WBC, DC
and platelet count), serum biochemical analysis (glucose, total protein, ALP and acid
phosphatase), heat shock protein 47 expression and histopathological evaluation were
done in all the groups on day 0, 7 and 14..
The percentage of wound re-epithelialisation, wound contraction and wound
healing were significantly (p
 
Date 2016-05-24T16:58:06Z
2016-05-24T16:58:06Z
2014
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/66288
 
Language en
 
Format application/pdf
 
Publisher Tamil Nadu Veterinary and Animal Sciences University