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Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats.

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Title Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats.
 
Creator Rahangadale, S. P.
 
Contributor Kurkure, N. V.
 
Subject Veterinary Pathology
Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats.
 
Description Acrylamide is commonly used in both industries and laboratories.
Acrylamide is rapidly absorbed following oral administration in all species and
regardless of the route of administration. Acrylamide is metabolized to
glycidamide by an epoxidation reaction. Neurotoxic and non neurotoxic effects of
this dreadful substance include genotoxicity, reproductive toxicity and
carcinogenicity. Vitamin E is one of four fat-soluble vitamins used widely to protect
tissue from oxidative stress injuries.
The present study was carried out to investigate the effects of different
doses of acrylamide and ameliorative effect of vitamin E on clinical signs,
functional observational battery (FOB), body weight, haemato-biochemical
parameters, reproductive parameters, gross & histopathological findings in male
rats. Wistar rats were given acrylamide @ 20 mg/kg and vitamin E 50IU/kg B.W.
orally for 28 days and 42 days. During the experimental period animals exhibited
clinical signs like weakness, splaying and dragging of hind limbs. FOB revealed a
significant change in CNS, neuromuscular and autonomic domains. At recovery
period vitamin E treated group showed improvement in clinical signs. There was
significant reduction in body weight was recorded on 21st, 28th, 35th and 42nd day
of experiment.
There was decrease in total leukocyte count. Significant decrease in
glucose values was noted of 28th days, but at 42 days experiment, Significant
increase in Serum Aspartate Aminotransferase (AST),Serum Alkaline Phosphates
(ALP) and decrease in total protein, albimin values was noted at both period of
study. There was significant decrease in total sperm and significant increase in
dead sperm count at 28th days period of study whereas at recovery period, there
was increase in total sperm count vitamin E treated animals of group E as
compare to group D.
Histopathological finding includes neuronal and spinal cord degeneration
degenerative changes in liver, kidneys and testes at 28th days study, During
recovery study, vitamin E treated group revealed partial protection of brain, spinal
cord and testes.
 
Date 2017-01-06T14:36:59Z
2017-01-06T14:36:59Z
2010-09-15
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/94858
 
Language en
 
Format application/pdf
 
Publisher MAFSU