Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats.
KrishiKosh
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Title |
Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats.
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Creator |
Rahangadale, S. P.
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Contributor |
Kurkure, N. V.
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Subject |
Veterinary Pathology
Toxicopathological Effects of Acrylamide and Ameliotative Effect of Vitamin in Male Wister Rats. |
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Description |
Acrylamide is commonly used in both industries and laboratories. Acrylamide is rapidly absorbed following oral administration in all species and regardless of the route of administration. Acrylamide is metabolized to glycidamide by an epoxidation reaction. Neurotoxic and non neurotoxic effects of this dreadful substance include genotoxicity, reproductive toxicity and carcinogenicity. Vitamin E is one of four fat-soluble vitamins used widely to protect tissue from oxidative stress injuries. The present study was carried out to investigate the effects of different doses of acrylamide and ameliorative effect of vitamin E on clinical signs, functional observational battery (FOB), body weight, haemato-biochemical parameters, reproductive parameters, gross & histopathological findings in male rats. Wistar rats were given acrylamide @ 20 mg/kg and vitamin E 50IU/kg B.W. orally for 28 days and 42 days. During the experimental period animals exhibited clinical signs like weakness, splaying and dragging of hind limbs. FOB revealed a significant change in CNS, neuromuscular and autonomic domains. At recovery period vitamin E treated group showed improvement in clinical signs. There was significant reduction in body weight was recorded on 21st, 28th, 35th and 42nd day of experiment. There was decrease in total leukocyte count. Significant decrease in glucose values was noted of 28th days, but at 42 days experiment, Significant increase in Serum Aspartate Aminotransferase (AST),Serum Alkaline Phosphates (ALP) and decrease in total protein, albimin values was noted at both period of study. There was significant decrease in total sperm and significant increase in dead sperm count at 28th days period of study whereas at recovery period, there was increase in total sperm count vitamin E treated animals of group E as compare to group D. Histopathological finding includes neuronal and spinal cord degeneration degenerative changes in liver, kidneys and testes at 28th days study, During recovery study, vitamin E treated group revealed partial protection of brain, spinal cord and testes. |
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Date |
2017-01-06T14:36:59Z
2017-01-06T14:36:59Z 2010-09-15 |
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Type |
Thesis
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Identifier |
http://krishikosh.egranth.ac.in/handle/1/94858
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Language |
en
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Format |
application/pdf
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Publisher |
MAFSU
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