Studies on effect of Ashwagandha (Withania somnifera) on chlorpyrifos toxicity in broiler chicks
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Title |
Studies on effect of Ashwagandha (Withania somnifera) on chlorpyrifos toxicity in broiler chicks
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Creator |
Bishnoi, Nidhi
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Contributor |
Jakhar, K. K.
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Subject |
Chicks, Chlorpyrifos toxicity, Ashwagandha, Withania somnifera
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Description |
The present study was undertaken in 150 broiler chicks to access the effects of Ashwagandha on CPF toxicity. The chicks (10 days of age) were divided randomly into 3 groups viz. group A, B and C containing 50 chicks each. All the birds of group A were provided with normal feed and water, that of group B with Ashwagandha @ 0.2 per cent of feed and that of group C with Ashwagandha @0.5 per cent of feed, throughout the experiment. At the age of 17 days these three groups were further subdivided into group A1, A2, group B1, B2 and group C1, C2, respectively. Out of these subgroups group A2, B2 and C2 were treated with 1/5 th of MTD of CPF orally through drops, for next 28 days. Clinical signs were weakness, depression, salivation, mucoid and bloody diarrhoea. CPF intoxicated group A2 showed significantly lower mean body weight as compared to groupA1 which was found increased in groups B2 and C2. There was significant increase in mean serum AST, ALT, AKP, CPK, activities in CPF intoxicated groups as compared to group A1. However, their activity was decreased in groups B2 and C2. Mean ChE activity in whole blood, plasma and RBC was found to be significantly lower in all the CPF treated groups as compared to control which was also found to be inhibited in groups B2 and C2. There was a decrease in mean SOD and CAT values in group A2 whereas these increased in groups B2 and C2. Gross pathological studies revealed anaemic carcass, mildly congested lungs, heart, congestion in liver, kidneys, brain, bursa of Fabricius; splenomegaly. The histopathological lesions observed were congestion, focal areas of necrosis and bile duct hyperplasia in liver, thickening of interlobular septa in lungs, serofibrinous exudate in the pericardium, congestion in serosa, infiltration of mononuclear cells in submucosa of intestine, coagulative necrosis in kidneys, depletion of lymphocytes in spleen, necrosis of pancreatic acinar cells and degenerative changes in neurons. The HMI was lowered on CPF intoxication which nonsignificantly increased groups B2 and C2. CPF intoxication caused significantly lower values of LPA. Ashwagandha enhanced the CMI which was significant in chicks of group C2. Based on these studies it is concluded that Ashwagandha supplementation had ameliorating effect on chlorpyrifos toxicity in broiler chicken which was more at 0.5 percent supplementation. |
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Date |
2016-08-17T10:09:05Z
2016-08-17T10:09:05Z 2015 |
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Type |
Thesis
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Identifier |
http://krishikosh.egranth.ac.in/handle/1/72682
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Language |
en
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Format |
application/pdf
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Publisher |
LUVAS
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