Influence of Toxin Binders on the Pharmacokinetics and Bioavailability of Enrofloxacin in Broiler chicken
KrishiKosh
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Title |
Influence of Toxin Binders on the Pharmacokinetics and Bioavailability of Enrofloxacin in Broiler chicken
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Creator |
Mekala, P.
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Contributor |
Jagadeeswaran, A.
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Subject |
Enrofloxacin
HSCAS Activated charcoal Interaction kinetics Interaction Bioavailability |
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Description |
A study on the interaction kinetics of the drug enrofloxacin with commonly used toxin binders viz. hydrated sodium calcium aluminosilicate (HSCAS) and activated charcoal (AC) was conducted in broiler chicken. Ninety six apparently healthy commercial broiler chicken of six weeks age, divided into eight groups of twelve each were used to explore the pharmacokinetics of enrofloxacin after single intravenous bolus, oral bolus and pulse dosing (drinking water) at a dose rate of 10mg.kg^-1 b.wt. Interaction kinetics was studied after single (10mg.kg^-1) and multiple pulse dosing (10mg.kg^-1 for 5 days) by comparing enrofloxacin alone treated group with groups supplemented with either HSCAS or AC through feed at the rate of 0.5 per cent. Blood samples were collected from all the groups at predetermined time intervals and enrofloxacin concentrations in plasma were analyzed by HPLC method and pharmacokinetic parameters such as AUC, Vd area, ClB, t1/2, Cmax, tmax, Cp and F were calculated. Comparison of the mean pharmacokinetic parameters revealed significant (p |
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Date |
2016-07-26T17:04:35Z
2016-07-26T17:04:35Z 2014 |
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Type |
Thesis
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Identifier |
http://krishikosh.egranth.ac.in/handle/1/69974
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Language |
en
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Format |
application/pdf
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Publisher |
Tamil Nadu Veterinary and Animal Sciences University
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