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CLINICAL STUDIES ON CANINE MAMMARY TUMORS

KrishiKosh

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Title CLINICAL STUDIES ON CANINE MAMMARY TUMORS
Ph.D;CVSc;TPTY; Acc No:T1282
 
Creator VEENA, PODARALA
 
Contributor SURESH KUMAR, R.V (Major)
Raghavender, K.B.P
CHANDRASEKHARA RAO, T.S
SRILATHA, Ch
 
Subject CANINE ; MAMMARY TUMORS
 
Description THESES
ABSTRACT:

The present clinical study was conducted on 72 dogs with canine
mammary tumors. 71 dogs were females and one dog was a male. Highest
incidence of CMTs was observed in the age group of 10-12 years. Majority of
the cases reported were nulliparous followed by pleuriparous and uniparous.
Spitz was the most commonly affected dog breed. Inguinal pair was the most
commonly affected gland. All the tumors varied widely in size ranging from 2 -
12 cms. Most of the tumors were nodular and a few were cystic in nature. All
the cases with ulcerations were found to be malignant.
Physiological parameters and hematological parameters were evaluated
and no significant difference was found between the groups. Thoracic
radiographs revealed distant metastases in 9 dogs as well defined nodules or
masses (cannon balls), solitary nodule, multiple small nodules and diffuse
interstitial pattern. Ultrasonography found helpful to rule out abdominal
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metastases and to know the presence of anechoic fluid filled cystic spaces.
Electron microscopic studies disclosed no viral etiology in mammary
carcinogenesis. Diagnostic cytology techniques like FNAB, NAF cytology
established the malignancy in tumors. C-reactive protein values and AgNOR
counts differentiated the malignant tumors from the benign tumors. The mean
AgNoR count for all individuals varied from 2.38 to 8.32.
Histopathological examination revealed 18 benign and 54 malignant
CMTs. Adenocarcinomas were the most frequently encountered malignant
CMTs. Immuno histochemical studies were carried out on 24 malignant CMTs
and majority of the tumors (75%) were found to have hormonal receptor positive
expression. Majority of adenocarcinomas (70%) were expressing PR positivity.
Proliferative markers like P53, C-erb B2 oncogene expression was studied and
found in 20.83% and 25% of malignant CMTs respectively. Treatment
modalities like surgical excision / chemotherapy / surgery and chemotherapy /
surgery and hormonal therapy were adopted. In chemotherapy, neutropenia
was observed. Lethargy, vomition, anorexia were the side effects of
chemotherapy observed which subsided by administration of supportive
therapy. Doxorubicin and Cyclophosphamide were the anti cancer drugs used
in the chemotherapy. Dogs with hormonal receptor positive CMTs were given
hormonal therapy with tab. Tamoxifen.
In the present study a combination of surgical excision of CMTs and
adjunctive hormonal therapy gave the best results with no recurrence of the
tumor mass compared to the other treatment modalities. Majority of the animals
had no recurrence of tumor growth. Chemotherapy along with surgical excision
of CMTs gave better results with 72% of disease free interval. Surgical excision
remains the best treatment modality, still unprecedented for the treatment of
localized or low grade or benign tumors. Variable results and toxic side effects
were recorded in the treatment of CMTs with chemotherapy alone and found to
be palliative.
DEPARTMENT OF VETERINARY SURGERY AND RADIOLOGY,
COLLEGE OF VETERINARY SCIENCE, TIRUPATI,
SRI VENKATESWARA VETERINARY UNIVERSITY, TIRUPATI - 517502
 
Date 2016-12-22T10:32:33Z
2016-12-22T10:32:33Z
2009-05
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/92050
 
Language en
 
Format application/vnd.openxmlformats-officedocument.wordprocessingml.document
 
Publisher Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P