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Biochemical, Histopathological and Ultra Structural Profile After Pulsed Water Medication of Enrofloxacin in Broiler Chickens

KrishiKosh

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Title Biochemical, Histopathological and Ultra Structural Profile After Pulsed Water Medication of Enrofloxacin in Broiler Chickens
Vet World 6(9): 668-673
 
Creator Sureshkumar, Veerapandian
Sarathchandra, Ghadevaru
Ramesh, Jayaramachandran
 
Subject Biochemical parameters
Broiler chickens
Enrofloxacin
Histopathology
Ultrastructural
Veterinary pharmacovigilance
 
Description Aim: A pharmacological study was undertaken to evaluate the safety and adverse effects of enrofloxacin administration in broiler chickens by assessing the serum biochemical parameters, associated histopathological and ultra structural changes in liver and kidney.
Materials and Methods: Birds in the treatment group were administered with enrofloxacin at the recommended therapeutic dose 10mg/kg body weight via drinking water for five successive days, while the control group (untreated group) received non medicated water. Serum biochemical parameters viz., total protein, albumin, lactate dehydrogenase, alkaline phosphatase, creatine kinase, lipase, triglyceride, gamma glutamyl transferase, urea, uric acid and creatinine were estimated at 24hour and 48hour intervals during the dosing and withdrawal periods, respectively. Liver and kidney tissue samples collected from 1, 3, 5, 7, and 9 days post treatment groups were subjected to histopathological and ultrastructural examinations.
Results: There was no significant change (p>0.05) in total protein, albumin, lactate dehydrogenase, alkaline phosphatase, creatine kinase, lipase, triglyceride and urea levels in the enrofloxacin administered broiler chickens at all the time points evaluated. However, a significant increase (p
 
Date 2016-06-11T14:58:38Z
2016-06-11T14:58:38Z
2013-09
 
Type Article
 
Identifier http://krishikosh.egranth.ac.in/handle/1/67215
 
Language en
 
Format application/pdf
 
Publisher Veterinary World