ICAR Research Data Repository for Knowledge Management
Synthesis of bioactive molecules using novel methods and evaluation of their biological activities
KrishiKosh
View Archive Info| Field | Value | |
| Title |
Synthesis of bioactive molecules using novel methods and evaluation of their biological activities
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| Creator |
Pandey, Jyoti
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| Contributor |
Virendra Kumar
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| Subject |
biochemistry, molecular biology, herbicides, weed control, chemical control
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| Description |
Thesis-PhD
Five series of compounds namely cinnamic acid amides, ß-benzoylacrylic acid esters, 1, 5 benzodiazepines, benzimidazoles and .-acetamido keto esters were synthesized. Analogues of naturally occurring cinnamic acid amides and ß-benzoylacrylic acid esters were synthesized in order to evaluate their herbicidal potential against Echinochola colona (weed of rice) and Phalaris minor (weed of wheat) respectively. Some of the analogues of cinnamic acid amides and ß-benzoacrylic acid esters exhibited activity at par with the standards. Benzodiazepines, benzimidazoles and .-acetamido keto esters were undertaken in order to develop new techniques and catalysts. A new catalyst trichloro acetic acid was developed for the synthesis of benzodiazepines by the reaction of o-phenylenediamine and substituted aldehydes. Some of the synthesized benzodiazepines were found to antibacterial and duodenal smooth muscle relaxation activity. For the synthesis of benzimidazoles two new catalyst ferric chloride and silica supported calcium chloride dihydrate have been developed as novel and efficient catalysts. For the synthesis of .-acetamido keto esters two new catalyst oxalic acid and calcium chloride dihydrate have been developed. |
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| Date |
2016-09-09T09:27:56Z
2016-09-09T09:27:56Z 2010-08 |
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| Type |
Thesis
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| Identifier |
http://krishikosh.egranth.ac.in/handle/1/76188
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| Language |
en
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| Format |
application/pdf
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| Publisher |
G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand)
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