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A study report on understanding the molecular interaction of suitable miRNAs and mRNA pairs involved in multiple solid tumors for better targeting

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Title A study report on understanding the molecular interaction of suitable miRNAs and mRNA pairs involved in multiple solid tumors for better targeting
 
Creator Das, Debashrita
 
Contributor Badireenathkonkima, V
 
Subject micro RNAs, Gene function, PTEN, solid tumors, Minimum free energy, Ago protein
 
Description In the current study, 7 different types of solid cancers were studied i.e, lung, breast, colorectal, Prostate,
Pancreatic, Bladder, Stomach. From literature, 23 miRNA targeting 63 genes were reported for these 7
tumor types. These genes have various functions in physiology such as Angiogenesis, Apoptosis, Cell
cycle, Cell proliferation, and some other genes have other functions. The mRNA and miRNA were
profiled in terms of Minimum free energy score, number of miRNA and mRNA interaction, role in a
cancer type, etc. From the study it was identified that PTEN gene (mRNA) and miR-21 (miRNA) have a
commonality in all 7 types of cancers studied. Of these, it has very high significance in Pancreatic cancer,
Colorectal cancer, Stomach cancer and in the rest of the 5 cancers such as, Bladder cancer, Lung cancer,
Breast cancer, Prostate Cancer, Pancreatic cancer it is of low significance. Therefore, targeting PTEN by
silencing with miR-21 would be a rational approach to suppress the cancerous condition.The structural
interaction between miRNA-mRNA duplex and Ago protein has been studied. The interacting residue
found as conserved in all docking operation between miRNA-mRNA duplex and Ago protein.
 
Date 2017-01-04T14:30:33Z
2017-01-04T14:30:33Z
2015
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/94470
 
Language en
 
Relation Th;4349
 
Format application/pdf