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Pathomorphological and Immunosuppressive Studies on Induced Aflatoxicosis and its Amelioration Using Diatomaceous Earth (Dae) in Broiler Chicken

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Title Pathomorphological and Immunosuppressive Studies on Induced Aflatoxicosis and its Amelioration Using Diatomaceous Earth (Dae) in Broiler Chicken
 
Creator Avinash Warundeo Lakkawar
 
Contributor Satyanarayana, M.L.
Balasubramaniam, G.A.
Narayan Swamy, H.D.
Suguna Rao
Yathiraj, S.
Shridhar, N.B.
Shrikrishna Isloor
 
Subject Aflatoxin, broiler chicken, diatomaceous earth, growth rate, immunopathology.
 
Description Ph.D. Thesis
The study was conducted to evaluate the toxic effect of dietary levels of aflatoxin
(AF) and ameliorative effect of diatomaceous earth (DAE) in commercial broiler chicken
for 35 days. 360 day old broiler chicks were divided into nine groups. First three groups
were fed control diet, 400 mg DAE and 800 mg DAE/kg feed, respectively. Two groups
were fed 0.5 and 1 ppm aflatoxin, respectively in feed. In the four combination groups,
birds were supplemented with 400 and 800 mg DAE/kg feed along with 0.5 and 1 ppm of
AF, respectively. Decreased body weight, increased feed conversion ratio, increased
relative weights of liver, kidney, heart and pancreas and decrease in weights of thymus,
spleen and bursa of Fabricius were recorded in toxin fed birds. DAE supplementation
caused significant improvement in growth rate and organ weight. Feeding of AF alone
significantly decreased serum total proteins, albumin, triglycerides and cholesterol levels.
However, significant increase was found in AST, ALT, ALP, BUN and creatinine levels
in AF fed broilers. DAE Supplementation ameliorated the adverse effect on serum
biochemical parameters. Birds fed toxin showed lowered antibody titres against NDV and
IBDV and decreased CD4+ and CD8+ cells. Aflatoxin induced DNA fragmentation in
liver, kidneys and lymphoid organs. Birds fed with aflatoxin showed higher serum levels
of IL-6, TNFα, IL-8 mRNA expression in peripheral lymphocyte and decreased serum
level of IL-2. Pathomorphological lesions characteristic of aflatoxicosis were prominent
in liver, kidneys and lymphoid organs and DAE supplementation reduced severity of
lesions.
 
Date 2016-08-02T15:33:49Z
2016-08-02T15:33:49Z
2015-05-25
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/70622
 
Language en
 
Format application/pdf
 
Publisher Karnataka Veterinary, Animal and Fisheries Sciences University, Bidar