Record Details

Effect of Extracts of Crataeva religiosa on Hepatic Markers in Liver Intoxication

KrishiKosh

View Archive Info
 
 
Field Value
 
Title Effect of Extracts of Crataeva religiosa on Hepatic Markers in Liver Intoxication
Indian Vet. J., September 2015, 92 (9) : 86 - 88
 
Creator Jaikanth, C.M.
Venkateswaran, K.V.
Selvasubramanian, S.
Sesh, P.S.L.
 
Subject Crataeva religiosa
Paracetamol
LDH and GGT
 
Description The study was conducted to evaluate the hepatoprotective potentials of extracts of Crataeva religiosa in liver damaged rats and also to compare the efficacy of two extracts viz., aqueous and ethanolic extracts. Thirty six female Wistar rats used for the study were intoxicated on the first day of the study with an oral acute toxic dose of paracetamol at the rate of 3 g/kg b.w. Treatments were given from day 2 to day 8, with standard drug (silymarin at 100 mg/kg b.w.), test drug 1 at two doses (aqueous extract of C. religiosa at 200 and 400 mg/kg b.w.) and test drug 2 at two doses (ethanolic extract of C. religiosa at 200 and 400 mg/kg b.w.) respectively. Hepatic microsomal assays viz., lactate dehydrogenase (LDH) and gamma glutamyl transpeptidase (GGT) were carried out to test the efficacy of drugs. It was found that both the standard and test drugs were significant in restoring the elevated enzyme levels. It was further noticed that the ethanolic extract at 400 mg /kg b.w. had excelled as good as the standard drug, silymarin in restoring the elevated blood parameters.
 
Date 2016-06-08T16:25:18Z
2016-06-08T16:25:18Z
2015-09
 
Type Article
 
Identifier http://krishikosh.egranth.ac.in/handle/1/67051
 
Language en
 
Format application/pdf
 
Publisher Indian Veterinary Journal