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Antioxidant and hepatoprotective activity of fruit rind extract of <em>Garcinia </em>morella (Gaertn.) Desr.

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Title Statement Antioxidant and hepatoprotective activity of fruit rind extract of <em>Garcinia </em>morella (Gaertn.) Desr.
 
Added Entry - Uncontrolled Name Gogoi, Nabajyoti ; Dibrugarh University
Gogoi, Ankur ; Dibrugarh University
Neog, Bijoy ; Dibrugarh University
Baruah, Dibyojyoti ; Dibrugarh University
Singh, Khumanthem Deepak; Dibrugarh University,Assam
indian council of medical research (ICMR)
 
Uncontrolled Index Term Antioxidant, Free radicals, Garcinia morella (Gaertn.) Desr., Hepatoprotective
 
Summary, etc. The present work was undertaken to determine the <em>in vitro</em> antioxidant and <em>in vivo</em> hepatoprotective activity of traditionally used <em>Garcinia </em>morella (Gaertn.) Desr. (<em>Kuji </em>thekera in Assamese). Fruit rind extract of <em>G. morella</em> was studied to examine the antioxidant activity of different concentrations (100, 500, 1000 µg/mL) in various in vitro models viz; 2,2-diphenyl-1-picrylhydrazine (DPPH), 2, 2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Nitric Oxide (NO). Percentage Inhibition was exhibited in a dose dependent manner in all the models. Hepatoprotective activity was determined by measuring the activity of liver function enzymes such as aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and biochemical parameter like bilirubin, total protein in albino rats. Albino rats administrated with CCl<sub>4</sub> elevated the liver function enzymes and bilirubin, but suppressed the production of total protein. Pretreatment with the extract decreased the AST, ALT, ALP, and bilirubin level significantly and increased the production level of total protein in a dose dependent manner. The histopathological observation of liver sections supported the hepatoprotective activity of the extract. Phytochemical investigation revealed that both phenolic and flavonoids groups were present in the plant. Toxicological study confirmed that the plant is non toxic. The present study indicates that the methanolic fruit rind extract of G. morella may be an effective protective agent against the diseases caused by free radicals and it is a viable candidate for treating liver disorder.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-08-16 07:59:10
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/14436
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 2 (2017): June 2017
 
Language Note en
 
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