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Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12741/
http://dx.doi.org/10.1016/j.jff.2016.10.023
 
Title Chitosan-glycolipid nanocarriers improve the bioavailability of
fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant
activity in rat model.
 
Creator Ravi, Hindupur.
Baskaran, V.
 
Subject 14 Carotenoid Chemistry
 
Description In this study, we have hypothesized that fucoxanthin (FUCO) absorption from nanogels (NGs) may
increase. CS-NGs were prepared by using chitosan (CS) with/without GL and studied (i) the FUCO
bioavailability upon a single (48 h), repeated (14 d) and dietary (one month) feeding, (ii) the agonistic
property of FUCO and GL on PPARc and SRB1 expressions to examine active absorption of FUCO. In single
(pmol/mL/48 h) and repeated dose (nmol/mL) study, plasma FUCO was higher by 38.8, 227.5% and 73.3,
292.4% in CS-NGs + GL compared to CS-NGs (�GL) and control groups. In dietary study, plasma FUCO
(nmol/mL) was higher by 57.5, 400 and 287% in CS-NGs + GL compared to CS-NGs (�GL), seaweed and
control groups. Increased PPARc expression was evident in CS-NGs + GL group depicting GL and FUCO
acts an agonist. This is the first report demonstrating advantage of CS-NGs + GL for improved FUCO
bioavailability via passive and active transport through PPARc mediated SRB1 activation.
 
Publisher Elsevier
 
Date 2017
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/12741/1/Journal%20of%20Functional%20Foods%2028%20%282017%29%20215%E2%80%93226.pdf
Ravi, Hindupur. and Baskaran, V. (2017) Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model. Journal of Functional Foods, 28. pp. 215-226. ISSN 1756-4646