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Squalene modulates fatty acid metabolism: Enhanced EPA/DHA in obese/diabetic mice (KK-Ay) model.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12758/
http://dx.doi.org/10.1002/ejlt.201600006
 
Title Squalene modulates fatty acid metabolism: Enhanced
EPA/DHA in obese/diabetic mice (KK-Ay) model.
 
Creator Sangeetha, Ravi Kumar
Yamauchi, I.
Bhaskar, N.
 
Subject 17 Fatty Acid Chemistry
12 Metabolism
 
Description Biosynthesis of long-chain n-3 fatty acids from precursors is limited. In vivo effect of squalene (SQ) on
the metabolic fate of n-3 fatty acid precursors in obese/diabetic KK-Ay rodent model was evaluated in our
work. Soybean oil, being rich in ALA (18:3 n-3; a known precursor of EPA/DHA), was chosen as the n-3
fatty acid precursor rich source. A high-fat diet (20%) containing 7% soybean oil (SO) was fed to obesity/
diabetes-prone male KK-Ay mice (control). In the case of diets fed to test groups, soybean oil was
replaced with 5% SO and 2% SQ. HepaticDHAlevels increased (four fold) in SQ fed group over control
(p
 
Date 2016
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/12758/1/Eur.%20J.%20Lipid%20Sci.%20Technol.%202016%2C%20118%2C%201935%E2%80%931941.pdf
Sangeetha, Ravi Kumar and Yamauchi, I. and Bhaskar, N. (2016) Squalene modulates fatty acid metabolism: Enhanced EPA/DHA in obese/diabetic mice (KK-Ay) model. European Journal of Lipid Science and Technology, 118. pp. 1935-1941.