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Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/12816/
http://dx.doi.org/10.1177/0885328215590753
 
Title Chitosan-glycolipid nanogels loaded
with anti-obese marine carotenoid
fucoxanthin: Acute and sub-acute
toxicity evaluation in rodent model.
 
Creator Ravi, Hindupur.
Arunkumar, R.
Baskaran, V.
 
Subject 14 Carotenoid Chemistry
17 Toxicology
 
Description Fucoxanthin (FUCO) is a light- and heat-sensitive marine xanthophyll carotenoid, present in brown algae that render
physiological properties as anti-oxidants. In this study, nanoencapsulation is an approach adopted to improve bioavailability
of FUCO by using ionic-gelation method with polymeric chitosan (CS) dispersed in glycolipid (GL), as a carrier.
Further, the aim was to investigate adverse effect of acute and sub-acute toxicity of chitosan nanogels (CS-NGs) loaded
with FUCOþGL in rats. In the acute toxicity study, FUCO was fed to rats at doses of 0.1, 1, 10 and 100 mg/kg body
weight (BW). In the sub-acute toxicity study, FUCO was fed at doses of 1 and 10 mg/kg BW for 28 days. In both the
studies, no mortality and abnormalities in gross morphology were observed. Acute toxicity study revealed that the LD50
of FUCO in CS-NGs is higher than 100 mg/kg BW. No postprandial plasma levels of FUCO were detected. However,
fucoxanthinol (FUOH), a hydrolytic metabolite of FUCO was detected in a dose dependent manner (P
 
Date 2015
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/12816/1/Journal%20of%20Biomaterials%20Applications%202015.pdf
Ravi, Hindupur. and Arunkumar, R. and Baskaran, V. (2015) Chitosan-glycolipid nanogels loaded with anti-obese marine carotenoid fucoxanthin: Acute and sub-acute toxicity evaluation in rodent model. Journal of Biomaterials Applications. pp. 1-15.