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A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus

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Title A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus
 
Creator Sharma, Punita
Chauhan, Prashant S.
Dutt, Prabhu
Amina, Musarat
Suri, Krishan A.
Gupta, Bishan D.
Suri, Om P.
Dhar, Kanaya L.
Sharma, Deepak
Gupta, Vivek
Satti, Naresh K.
 
Subject Chemical Sciences
 
Description A new steroidal sapogenin molecule 1 having unique characteristics, 21-nor and unusual C19 carboxylic
acid has been isolated from the roots of Asparagus racemosus. On the basis of chemical evidence, extensive
spectroscopic analysis including two dimensional (2D) NMR and X-ray studies of single crystal,the structure of 1 was determined as(1S,2R,3S,8S,9S,10S,13S,14S,16S,17R,22R,25R)-21-nor-18�,27�-
dimethyl-1�,2�,3�-trihydroxy-25-spirost-4-en-19�-oic acid. 1 crystallizes in monoclinic space group P21 with a = 9.295(2), b = 11.238(2), c = 11.376(2)A˚ ; ˇ = 91.993(4)◦, Z = 2, Dcal = 1.344Mg/m3. The structure was solved by direct methods and refined by full-matrix least-squares procedure to a final R-value of 0.0561 for 4064 observed reflections. 1 was tested against the type of immune responses generated during treatment in normal and immune-suppressed animals and detailed biological activity evaluation suggests it to be a potent immunostimulator.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/199/1/10.1016j.steroids.2010.12.006.pdf
Sharma, Punita and Chauhan, Prashant S. and Dutt, Prabhu and Amina, Musarat and Suri, Krishan A. and Gupta, Bishan D. and Suri, Om P. and Dhar, Kanaya L. and Sharma, Deepak and Gupta, Vivek and Satti, Naresh K. (2011) A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus. Steroids, 76 (4). pp. 358-364. ISSN 0039128X
 
Relation http://dx.doi.org/10.1016/j.steroids.2010.12.006
http://iiim.csircentral.net/199/