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An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols

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Title An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols
 
Creator Gupta, Pankaj
Taneja, Subhash C.
Shah, Bhahwal A.
Mukherjee, Debaraj
Parshad, Rajinder
Chimni, Swapandeep S.
Qazi, Ghulam N.
 
Subject Chemical Sciences
 
Description The expedient synthesis of enantiopure masked 1,2-amino alcohols (ee >99%) including their alkyl substituted
analogues has been achieved by the regioselective ring opening of epoxides using phthalimide,followed by highly efficient kinetic resolution under mild and environmentally friendly conditions. The addition of co-solvents during kinetic resolution significantly improved the enantioselectivity with reduction in time.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/206/1/10.1016j.tetasy.2008.08.004.pdf
Gupta, Pankaj and Taneja, Subhash C. and Shah, Bhahwal A. and Mukherjee, Debaraj and Parshad, Rajinder and Chimni, Swapandeep S. and Qazi, Ghulam N. (2008) An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols. Tetrahedron: Asymmetry, 19 (16). pp. 1898-1903. ISSN 09574166
 
Relation http://dx.doi.org/10.1016/j.tetasy.2008.08.004
http://iiim.csircentral.net/206/