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Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners

IR@CSIR-IIIM

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Title Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
 
Creator Kamal, Ahmed
Shetti, Rajesh V.C.R.N.C.
Azeeza, Shaik
Ahmed, S. Kaleem
Swapna, P.
Reddy, A. Malla
Khan, Inshad Ali
Sharma, Sandeep
Abdullah, Sheikh Tasduq
 
Subject Pharmacological Sciences
 
Description In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine
1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC ΒΌ 1 mg/mL) is also discussed.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/214/1/10.1016j.ejmech.2010.07.015.pdf
Kamal, Ahmed and Shetti, Rajesh V.C.R.N.C. and Azeeza, Shaik and Ahmed, S. Kaleem and Swapna, P. and Reddy, A. Malla and Khan, Inshad Ali and Sharma, Sandeep and Abdullah, Sheikh Tasduq (2010) Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. European Journal of Medicinal Chemistry, 45 (10). pp. 4545-4553. ISSN 02235234
 
Relation http://dx.doi.org/10.1016/j.ejmech.2010.07.015
http://iiim.csircentral.net/214/