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Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones

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Title Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones
 
Creator Kamal, Ahmed
Shetti, Rajesh V.C.R.N.C.
Azeeza, Shaik
Swapna, P.
Khan, M. Naseer A.
Khan, Inshad Ali
Sharma, Sandeep
Abdullah, Sheikh Tasduq
 
Subject Chemical Sciences
 
Description As a part of investigation of new anti-tubercular agents in this laboratory, herein we describe the synthesis of a newclass of arylsulfonamido conjugated oxazolidinones. The in vitro activity of these conjugated (6aef,7aed, 9aec and 11aec) molecules against Mycobacterium tuberculosis H37Rv by using rifampicin and linezolide as positive controls is discussed, compounds 7c and 9aec are found to be the most active members in this series. Further, cytotoxicity of the potent conjugates of the series (7c, and 9aec) was
evaluated on human foreskin fibroblast (HFF) cells by using MTT assay. Finally, these studies suggest that compounds 7c and 9a mayserve as promising lead scaffolds for further generation of newas anti-TB agents.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/215/1/10.1016j.ejmech.2010.12.028.pdf
Kamal, Ahmed and Shetti, Rajesh V.C.R.N.C. and Azeeza, Shaik and Swapna, P. and Khan, M. Naseer A. and Khan, Inshad Ali and Sharma, Sandeep and Abdullah, Sheikh Tasduq (2011) Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones. European Journal of Medicinal Chemistry, 46 (3). pp. 893-900. ISSN 02235234
 
Relation http://dx.doi.org/10.1016/j.ejmech.2010.12.028
http://iiim.csircentral.net/215/