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Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains

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Title Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains
 
Creator Anand, Naveen
Kapoor, Munish
Ahmad, Khursheed
Koul, Surrinder
Parshad, Rajinder
Manhas, Kuldip S.
Sharma, Rattan L.
Qazi, Ghulam N.
Taneja, Subhash C.
 
Subject Chemical Sciences
 
Description The native strain of Arthrobacter sp. (MTCC 5125) bearing a lipase has been found to be the most effective in the kinetic resolution of racemic arylazetidinones for producing cis-(3R,4S)-3-acetoxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone, cis-(3R,4R)-3-acetoxy-1-(4-methoxyphenyl)-4-(2-furanyl)-2-azetidinone, cis-(3R,4R)-3-acetoxy 1-(4-methoxyphenyl)-4-(2-thienyl)-2-azetidinone, and cis-3-acetoxy-4-(t-butyl)-2-azetidinone products. The resolved compounds, which were obtained in high enantiopurity are important intermediates of amino acid side chains of paclitaxel
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/221/1/10.1016j.tetasy.2007.04.031.pdf
Anand, Naveen and Kapoor, Munish and Ahmad, Khursheed and Koul, Surrinder and Parshad, Rajinder and Manhas, Kuldip S. and Sharma, Rattan L. and Qazi, Ghulam N. and Taneja, Subhash C. (2007) Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains. Tetrahedron: Asymmetry, 18 (9). pp. 1059-1069. ISSN 09574166
 
Relation http://dx.doi.org/10.1016/j.tetasy.2007.04.031
http://iiim.csircentral.net/221/