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Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum

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Title Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum
 
Creator Goswami, Abhishek
Saikia, Partha P.
Barua, Nabin C.
Bordoloi, Manobjyoti
Yadav, Archana
Bora, Tarun C.
Gogoi, Binod K.
Saxena, Ajit Kumar
Suri, Nithasa
Sharma, Madhunika
 
Subject Pharmacological Sciences
 
Description Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using
soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS–MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/223/1/10.1016j.bmcl.2009.10.097.pdf
Goswami, Abhishek and Saikia, Partha P. and Barua, Nabin C. and Bordoloi, Manobjyoti and Yadav, Archana and Bora, Tarun C. and Gogoi, Binod K. and Saxena, Ajit Kumar and Suri, Nithasa and Sharma, Madhunika (2010) Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum. Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 359-361. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2009.10.097
http://iiim.csircentral.net/223/