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Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives

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Title Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives
 
Creator Sondhi, Sham M.
Rani, Reshma
Roy, Partha
Agrawal, S.K.
Saxena, A.K.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine
and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg p.o. compounds 3a (36.6%), 3d (32%), 4d (31.0%) and 4e(33.8%) exhibited good anti-inflammatory activity, comparable to standard drug ibuprofen which showed
39% activity at 50 mg/kg p.o.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/234/1/10.1016j.ejmech.2009.11.030.pdf
Sondhi, Sham M. and Rani, Reshma and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2010) Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives. European Journal of Medicinal Chemistry, 45 (3). pp. 902-908. ISSN 02235234
 
Relation http://dx.doi.org/10.1016/j.ejmech.2009.11.030
http://iiim.csircentral.net/234/