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Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids

IR@CSIR-IIIM

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Title Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids
 
Creator Shah, Bhahwal A.
Kumar, Ajay
Gupta, Pankaj
Sharma, Madhunika
Sethi, Vijay K.
Saxena, Ajit K.
Singh, Jaswant
Qazi, Ghulam N.
Taneja, Subhash C.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description 4-Amino analogues prepared from b-boswellic acid and 11-keto-b-boswellic acid, wherein the carboxyl group in ursane
nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/235/1/10.1016j.bmcl.2007.10.011.pdf
Shah, Bhahwal A. and Kumar, Ajay and Gupta, Pankaj and Sharma, Madhunika and Sethi, Vijay K. and Saxena, Ajit K. and Singh, Jaswant and Qazi, Ghulam N. and Taneja, Subhash C. (2007) Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bioorganic & Medicinal Chemistry Letters, 17 (23). pp. 6411-6416. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2007.10.011
http://iiim.csircentral.net/235/