Record Details

Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents

IR@CSIR-IIIM

View Archive Info
 
 
Field Value
 
Title Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents
 
Creator Reddy, Pitta B.
Paul, David V.
Agrawal, Satyam K.
Saxena, Ajit K.
Kumar, Halmuthur M. S.
Qazi, Ghulam N.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description A series of 4b-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized
with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4b-azido podophyllotoxin and C4b-azido-49-O-demethyl podophyllotoxin.All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 49-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells.
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/237/1/10.1002ardp.200700116.pdf
Reddy, Pitta B. and Paul, David V. and Agrawal, Satyam K. and Saxena, Ajit K. and Kumar, Halmuthur M. S. and Qazi, Ghulam N. (2008) Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents. Archiv der Pharmazie, 341 (2). pp. 126-131. ISSN 03656233
 
Relation http://dx.doi.org/10.1002/ardp.200700116
http://iiim.csircentral.net/237/