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Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent

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Title Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent
 
Creator Sharma, S.
Khan, I. A.
Ali, I.
Ali, F.
Kumar, M.
Kumar, A.
Johri, R. K.
Abdullah, S. T.
Bani, S.
Pandey, A.
Suri, K. A.
Gupta, B. D.
Satti, N. K.
Dutt, P.
Qazi, G. N.
 
Subject Pharmacological Sciences
 
Description Hydroxychavicol isolated from the chloroform extraction of aqueous extract of Piper betle leaves showed inhibitory activity against oral cavity pathogens. It exhibited an inhibitory effect on all of the oral cavity pathogens tested (MICs of 62.5 to 500 �g/ml) with a minimal bactericidal concentration that was twofold greater than the inhibitory concentration. Hydroxychavicol exhibited concentration-dependent killing of Streptococcus
mutans ATCC 25175 up to 4� MIC and also prevented the formation of water-insoluble glucan. Interestingly, hydroxychavicol exhibited an extended postantibiotic effect of 6 to 7 h and prevented the emergence of mutants of S. mutans ATCC 25175 and Actinomyces viscosus ATCC 15987 at 2� MIC. Furthermore,it also inhibited the growth of biofilms generated by S. mutans and A. viscosus and reduced the preformed biofilms by these bacteria. Increased uptake of propidium iodide by hydroxychavicol-treated cells of S. mutans and A. viscosus indicated that hydroxychavicol probably works through the disruption of the permeability
barrier of microbial membrane structures. Hydroxychavicol also exhibited potent antioxidant and anti-inflammatory
activities. This was evident from its concentration-dependent inhibition of lipid peroxidation and significant suppression of tumor necrosis factor alpha expression in human neutrophils. Its efficacy against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose suggests that hydroxychavicol would be a useful compound for the development of antibacterial agents against oral pathogens and that it has great potential for use in mouthwash for preventing and treating oral infections.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/255/1/10.1128AAC.00045-08.pdf
Sharma, S. and Khan, I. A. and Ali, I. and Ali, F. and Kumar, M. and Kumar, A. and Johri, R. K. and Abdullah, S. T. and Bani, S. and Pandey, A. and Suri, K. A. and Gupta, B. D. and Satti, N. K. and Dutt, P. and Qazi, G. N. (2009) Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent. Antimicrobial Agents and Chemotherapy, 53 (1). pp. 216-222. ISSN 0066-4804
 
Relation http://dx.doi.org/10.1128/AAC.00045-08
http://iiim.csircentral.net/255/