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Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity

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Title Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity
 
Creator Chandan, B.K.
Saxena, A.K.
Shukla, Sangeeta
Sharma, Neelam
Gupta, D.K.
Suri, K.A.
Suri, Jyotsna
Bhadauria, M.
Singh, B.
 
Subject Pharmacological Sciences
 
Description Aloe barbadensis Mill. Syn. Aloe vera Tourn. ex Linn.(Liliaceae) has been used in variety of diseases in traditional Indian system of medicine in India and its use for hepatic ailments is also documented. In the present study an attempt has been made to validate its hepatoprotective activity. The shade dried aerial parts of Aloe barbadensis were extracted with petroleum ether (AB-1), chloroform (AB-2) and methanol (AB-3).The plant marc was extracted with distilled water (AB-4). All the extracts were evaluated for hepatoprotective activity on limited test models as hexobarbitone sleep time, zoxazolamine paralysis time and marker biochemical parameters. AB-1 and AB-2 were observed to be devoid of
any hepatoprotective activity. Out of two active extracts (AB-3 and AB-4), the most active AB-4 was studied in detail. AB-4 showed significant hepatoprotective activity against CCl4 induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, bilirubin and triglycerides. Hepatoprotective potential was confirmed by the restoration of lipid peroxidation, glutathione, glucose-6-phosphatase and microsomal aniline hydroxylase and amidopyrine N-demethylase towards near normal. Histopathology of the liver tissue further supports the biochemical findings confirming the hepatoprotective potential of AB-4. The present study shows that the aqueous extract of Aloe barbadensis is significantly capable of restoring integrity of hepatocytes indicated by improvement in physiological parameters, excretory capacity (BSP
retention) of hepatocytes and also by stimulation of bile flow secretion. AB-4 did not show any sign of toxicity up to oral dose of 2 g/kg in mice
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/259/1/10.1016j.jep.2007.01.008.pdf
Chandan, B.K. and Saxena, A.K. and Shukla, Sangeeta and Sharma, Neelam and Gupta, D.K. and Suri, K.A. and Suri, Jyotsna and Bhadauria, M. and Singh, B. (2007) Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. Journal of Ethnopharmacology, 111 (3). pp. 560-566. ISSN 03788741
 
Relation http://dx.doi.org/10.1016/j.jep.2007.01.008
http://iiim.csircentral.net/259/