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Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa

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Title Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa
 
Creator Gupta, Amit
Khajuria, Anamika
Singh, Jaswant
Bedi, K.L.
Satti, N.K.
Dutt, Prabhu
Suri, K.A.
Suri, O.P.
Qazi, G.N.
 
Subject Pharmacological Sciences
 
Description In the last three decades, numerous biopolymeric fractions have been isolated from medicinal plants and used as a source of therapeutic agents. The most promising biopharmacological activities of these biopolymers are their immunomodulatory effects.The biopolymeric fraction RLJ-NE-205 was isolated and purified from the rhizomes of Picrorhiza kurroa. We evaluated the effects of biopolymeric fraction RLJ-NE-205 from P. kurroa on the in vivo immune function of the mouse. Balb/c mice were treated with the biopolymeric fraction RLJ-NE-205 (12.5, 25 and 50 mg/kg body weight) for 14 days with sheep red blood cells (SRBC) as an antigen. Haemagglutination antibody (HA) titre, plaque forming cell (PFC) assay, delayed type hypersensitivity (DTH) reaction,phagocytic index, proliferation of lymphocytes, analysis of cytokines in serum and CD4/CD8 population in spleen (determined by
flowcytometry) were studied. At the dose of 50 mg/kg, significant increases in the proliferation of lymphocytes (p
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/266/1/10.1016j.intimp.2006.05.002.pdf
Gupta, Amit and Khajuria, Anamika and Singh, Jaswant and Bedi, K.L. and Satti, N.K. and Dutt, Prabhu and Suri, K.A. and Suri, O.P. and Qazi, G.N. (2006) Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa. International Immunopharmacology, 6 (10). pp. 1543-1549. ISSN 15675769
 
Relation http://dx.doi.org/10.1016/j.intimp.2006.05.002
http://iiim.csircentral.net/266/