ICAR Research Data Repository for Knowledge Management
Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities
IR@CSIR-IIIM
View Archive Info| Field | Value | |
| Title |
Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities
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| Creator |
Sondhi, Sham M.
Rani, Reshma Roy, Partha Agrawal, S.K. Saxena, A.K. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
A number of N-substituted cyclic imides 3a–e, 5a–e, 7a–d, and 9a–e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation.These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/291/1/10.1016j.bmcl.2008.07.048.pdf
Sondhi, Sham M. and Rani, Reshma and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2009) Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Bioorganic & Medicinal Chemistry Letters, 19 (5). pp. 1534-1538. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2008.07.048
http://iiim.csircentral.net/291/ |
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