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Modulation of P-glycoprotein ATPase activity by some phytoconstituents

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Title Modulation of P-glycoprotein ATPase activity by some phytoconstituents
 
Creator Najar, I. A.
Sachin, B. S.
Sharma, S. C.
Satti, N. K.
Suri, K. A.
Johri, R. K.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description In the present investigation 16 phytoconstituents, which are active moieties found in several medicinal herbs,
have been evaluated for their P-glycoprotein (P-gp) stimulation/inhibition profi les using a P-gp-dependent
ATPase assay in rat jejunal membrane (in vitro). Acteoside, agnuside, catechin, chlorogenic acid, picroside -II
and santonin showed an inhibitory effect. Negundoside, picroside -I and oleanolic acid caused a stimulatory
effect. Andrographolide, apocyanin, berberine,glycyrrhizin, magniferin and piperine produced a biphasic response (stimulation at low concentration and inhibition at high concentration). The results suggested that a possible interaction of these phytoconstituents at the level of P-gp, could be an important parameter in determining
their role in several key pharmacodynamic events.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/293/1/10.1002ptr.2951.pdf
Najar, I. A. and Sachin, B. S. and Sharma, S. C. and Satti, N. K. and Suri, K. A. and Johri, R. K. (2010) Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytotherapy Research, 24 (3). pp. 454-458. ISSN 0951418X
 
Relation http://dx.doi.org/10.1002/ptr.2951
http://iiim.csircentral.net/293/