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Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus

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Title Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus
 
Creator Mirza, Z. M.
Kumar, A.
Kalia, N. P.
Zargar, A.
Khan, I. A.
 
Subject Pharmacological Sciences
 
Description Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the
mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mupr-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine ; with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2% mupirocin.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/311/2/10.1099jmm.0.033167-0.pdf
Mirza, Z. M. and Kumar, A. and Kalia, N. P. and Zargar, A. and Khan, I. A. (2011) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus. Journal of Medical Microbiology, 60 (10). pp. 1472-1478. ISSN 0022-2615
 
Relation http://dx.doi.org/10.1099/jmm.0.033167-0
http://iiim.csircentral.net/311/