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Protective Effect ofLabisia pumilaon Stress-Induced Behavioral, Biochemical, and Immunological Alterations

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Title Protective Effect ofLabisia pumilaon Stress-Induced Behavioral, Biochemical, and Immunological Alterations
 
Creator Kour, Kiranjeet
Sharma, Neelam
Chandan, Bal
Koul, Surrinder
Sangwan, Payare
Bani, Sarang
 
Subject Biological Sciences
Chemical Sciences
 
Description The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also showed the recovery of physical stress-induced depletion of neuromuscular coordination and scopolamine induced memory deficit. LPPM/A003 at graded doses reversed the chronic restraint stress (RST), induced depletion of CD4 and CD8 T lymphocytes, NK cell population, and corresponding cytokines expression besides downregulating the stress-induced increase in plasma corticosterone, a major stress hormone. In addition, LPPM/A003 reversed the chronic stress-induced increase in adrenal gland weight, serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and hepatic lipid peroxidation (LP) levels and augmented the RST induced decrease in hepatic glutathione (GSH), thymus and spleen weight. Thus, we conclude that LPPM/A003 has the ability to reverse the alterations produced by various stressful stimuli and therefore restores homeostasis.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/317/1/10.1055s-0029-1240953.pdf
Kour, Kiranjeet and Sharma, Neelam and Chandan, Bal and Koul, Surrinder and Sangwan, Payare and Bani, Sarang (2010) Protective Effect ofLabisia pumilaon Stress-Induced Behavioral, Biochemical, and Immunological Alterations. Planta Medica, 76 (14). pp. 1497-1505. ISSN 0032-0943
 
Relation http://dx.doi.org/10.1055/s-0029-1240953
http://iiim.csircentral.net/317/