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Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

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Title Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus
 
Creator Shah, Bhahwal Ali
Chib, Renu
Gupta, Pankaj
Sethi, Vijay Kumar
Koul, Surrinder
Andotra, Samar Singh
Nargotra, Amit
Sharma, Sujata
Pandey, Anjali
Bani, Sarang
Purnima, Basant
Taneja, Subhash Chandra
 
Subject Chemical Sciences
 
Description Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-a. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/335/1/10.1039b902041a.pdf
Shah, Bhahwal Ali and Chib, Renu and Gupta, Pankaj and Sethi, Vijay Kumar and Koul, Surrinder and Andotra, Samar Singh and Nargotra, Amit and Sharma, Sujata and Pandey, Anjali and Bani, Sarang and Purnima, Basant and Taneja, Subhash Chandra (2009) Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus. Organic & Biomolecular Chemistry, 7 (16). p. 3230. ISSN 1477-0520
 
Relation http://dx.doi.org/10.1039/b902041a
http://iiim.csircentral.net/335/