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Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils

IR@CSIR-IIIM

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Title Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils
 
Creator Bhat, Khurshid A.
Shah, Bhahwal A.
Gupta, Kuldeep K.
Pandey, Anjali
Bani, Sarang
Taneja, Subhash C.
 
Subject Chemical Sciences
 
Description Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-a expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-a cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/339/1/10.1016j.bmcl.2009.02.050.pdf
Bhat, Khurshid A. and Shah, Bhahwal A. and Gupta, Kuldeep K. and Pandey, Anjali and Bani, Sarang and Taneja, Subhash C. (2009) Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils. Bioorganic & Medicinal Chemistry Letters, 19 (7). pp. 1939-1943. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2009.02.050
http://iiim.csircentral.net/339/