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Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads

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Title Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
 
Creator Shah, Bhahwal Ali
Kaur, Rajbir
Gupta, Pankaj
Kumar, Ajay
Sethi, Vijay Kumar
Andotra, Samar Singh
Singh, Jaswant
Saxena, Ajit Kumar
Taneja, Subhash Chandra
 
Subject Chemical Sciences
 
Description Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure–activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa) and human myeloid leukemia (HL-60) cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead
molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/345/1/10.1016j.bmcl.2009.05.089.pdf
Shah, Bhahwal Ali and Kaur, Rajbir and Gupta, Pankaj and Kumar, Ajay and Sethi, Vijay Kumar and Andotra, Samar Singh and Singh, Jaswant and Saxena, Ajit Kumar and Taneja, Subhash Chandra (2009) Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4394-4398. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2009.05.089
http://iiim.csircentral.net/345/