ICAR Research Data Repository for Knowledge Management
Synthesis and biological activity of amide derivatives of nimbolide
IR@CSIR-IIIM
View Archive Info| Field | Value | |
| Title |
Synthesis and biological activity of amide derivatives of nimbolide
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| Creator |
Sastry, B.S.
Suresh Babu, K. Hari Babu, T. Chandrasekhar, S. Srinivas, P.V. Saxena, A.K. Madhusudana Rao, J. |
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| Subject |
Chemical Sciences
Pharmacological Sciences |
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| Description |
Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/349/1/10.1016j.bmcl.2006.05.105.pdf
Sastry, B.S. and Suresh Babu, K. and Hari Babu, T. and Chandrasekhar, S. and Srinivas, P.V. and Saxena, A.K. and Madhusudana Rao, J. (2006) Synthesis and biological activity of amide derivatives of nimbolide. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4391-4394. ISSN 0960894X |
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| Relation |
http://dx.doi.org/10.1016/j.bmcl.2006.05.105
http://iiim.csircentral.net/349/ |
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