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Synthesis and biological activity of amide derivatives of nimbolide

IR@CSIR-IIIM

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Title Synthesis and biological activity of amide derivatives of nimbolide
 
Creator Sastry, B.S.
Suresh Babu, K.
Hari Babu, T.
Chandrasekhar, S.
Srinivas, P.V.
Saxena, A.K.
Madhusudana Rao, J.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/349/1/10.1016j.bmcl.2006.05.105.pdf
Sastry, B.S. and Suresh Babu, K. and Hari Babu, T. and Chandrasekhar, S. and Srinivas, P.V. and Saxena, A.K. and Madhusudana Rao, J. (2006) Synthesis and biological activity of amide derivatives of nimbolide. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4391-4394. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2006.05.105
http://iiim.csircentral.net/349/