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Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

IR@CSIR-IIIM

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Title Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
 
Creator Bhat, B.A.
Dhar, K.L.
Puri, S.C.
Saxena, A.K.
Shanmugavel, M.
Qazi, G.N.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/350/1/10.1016j.bmcl.2005.03.121.pdf
Bhat, B.A. and Dhar, K.L. and Puri, S.C. and Saxena, A.K. and Shanmugavel, M. and Qazi, G.N. (2005) Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 15 (12). pp. 3177-3180. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2005.03.121
http://iiim.csircentral.net/350/