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Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents

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Title Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents
 
Creator Bhattacharya, Asish K.
Rana, Kalpeshkumar C.
Mujahid, Mohammad
Sehar, Irum
Saxena, Ajit K.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of b-naphthol with aryl aldehydes catalysed by TaCl5 under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-
14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues.Synthesized compound 3o showed IC50 of 37.9 and 41.3 lM against Colo-205 and 502713, respectively,whereas 3g showed IC50 of 41.9 lM against Colo-205.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/354/1/10.1016j.bmcl.2009.08.033.pdf
Bhattacharya, Asish K. and Rana, Kalpeshkumar C. and Mujahid, Mohammad and Sehar, Irum and Saxena, Ajit K. (2009) Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 19 (19). pp. 5590-5593. ISSN 0960894X
 
Relation http://dx.doi.org/10.1016/j.bmcl.2009.08.033
http://iiim.csircentral.net/354/