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Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors

IR@CSIR-IIIM

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Title Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors
 
Creator Saikam, Varma
Raghupathy, Riya
Yadav, Mahipal
Gannedi, Veeranjaneyulu
Singh, Parvinder Pal
Qazi, Naveed A.
Sawant, Sanghapal D.
Vishwakarma, Ram A.
 
Subject Chemical Sciences
 
Description The borondipyrromethene (BODIPY) labeled new glycosylphosphatidylinositol (GPI) molecules were synthesized as cellular probes to study the chemical basis of microdomain organization of GPI-anchored proteins and cholesterol in plasma membrane. The synthesis enabled by a new stereo-selective glycosylation of myo-D-inositol acceptor led to the preparation of optically pure glucosaminyl-(1-6)-a-phosphatidylmyo-D-inositol and its unnatural stereoisomer.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/355/1/10.1016j.tetlet.2011.06.005.pdf
Saikam, Varma and Raghupathy, Riya and Yadav, Mahipal and Gannedi, Veeranjaneyulu and Singh, Parvinder Pal and Qazi, Naveed A. and Sawant, Sanghapal D. and Vishwakarma, Ram A. (2011) Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors. Tetrahedron Letters, 52 (33). pp. 4277-4279. ISSN 00404039
 
Relation http://dx.doi.org/10.1016/j.tetlet.2011.06.005
http://iiim.csircentral.net/355/