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Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives

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Title Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives
 
Creator Sondhi, Sham M.
Singh, Jaiveer
Rani, Reshma
Gupta, P.P.
Agrawal, S.K.
Saxena, A.K.
 
Subject Chemical Sciences
Pharmacological Sciences
 
Description Condensation of 9-chloro-2,4-(un)substituted acridines (1a–c) with various amines (2a–e) and 9-isothiocyanato-
2,4-(un)substituted acridines (4a,b) with different amines (2a,b,d,e) gave condensed products 3a–o and 5a–g respectively. Compounds 3a–o and 5a–g were screened for anti-inflammatory activity at a dose of 50 mg/kg p.o. Compound 3e exhibited 41.17% anti-inflammatory activity which is better than most commonly used standard drug ibuprofen which showed 39% anti-inflammatory (at 50 mg/kg p.o.) activity. Anticancer activity evaluation of compounds 3a–o and 5a–g was carried out against a small panel of human cancer cell lines and compounds 3g, 3m and 5g exhibited good anticancer activity against breast (MCF-7), liver (HEP-2), colon (COLO-205, 502713, HCT-15), lung (A-549)and neuroblastoma (IMR-32) cancer cell lines at a concentration of 1� 10�5 M.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/358/1/10.1016j.ejmech.2009.10.042.pdf
Sondhi, Sham M. and Singh, Jaiveer and Rani, Reshma and Gupta, P.P. and Agrawal, S.K. and Saxena, A.K. (2010) Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. European Journal of Medicinal Chemistry, 45 (2). pp. 555-563. ISSN 02235234
 
Relation http://dx.doi.org/10.1016/j.ejmech.2009.10.042
http://iiim.csircentral.net/358/