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Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates

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Title Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates
 
Creator Koul, Surrinder
Koul, Jawahir Lal
Singh, Budh
Kapoor, Munish
Parshad, Rajinder
Manhas, Kuldeep S.
Taneja, Subhash C.
Qazi, Ghulam N.
 
Subject Chemical Sciences
 
Description A hydrolase producing strain Trichosporon beigelli esterase (TBE) isolated from local cottage cheese in its native form has displayed versatility and high efficacy in the kinetic resolution of a wide range of economically important substrates, which include racemic secondary alcohols, such as 1-(6-methoxy-2-naphthyl)ethanol (E � 316), 1-(3,4-methylenedioxyphenyl)ethanol and pentanol(E � 180 and 156 resp.), and alkyl esters of carboxylic acids such as ibuprofen (E � 340), 2-(benzylthio)propanoic acid
(E � 1000). In other substrates such as in the primary alcohol 2-(6-methoxy-2-naphthyl)propan-1-ol and carboxylic acids such as 2-(5-bromo-6-methoxy-2-naphthyl)propanoic acid, 2-(2-naphthyloxy)propanoic acid, and substituted 2-thiopropanoic acids, it displayed moderate to low selectivity. Commercial lipases such as CCL, PPL, and PSL were also used in the resolution of the substrates
for comparative studies.
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/365/1/10.1016j.tetasy.2005.07.009.pdf
Koul, Surrinder and Koul, Jawahir Lal and Singh, Budh and Kapoor, Munish and Parshad, Rajinder and Manhas, Kuldeep S. and Taneja, Subhash C. and Qazi, Ghulam N. (2005) Trichosporon beigelli esterase (TBE): a versatile esterase for the resolution of economically important racemates. Tetrahedron: Asymmetry, 16 (15). pp. 2575-2591. ISSN 09574166
 
Relation http://dx.doi.org/10.1016/j.tetasy.2005.07.009
http://iiim.csircentral.net/365/