Record Details

Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay

IR@CSIR-IHBT

View Archive Info
 
 
Field Value
 
Title Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay
 
Creator Sondhi, N
Bhardwaj, R
Kaur, S
Kumar, Neeraj
Singh , Bikram
 
Subject Natural Product Chemistry
 
Description Brassinosteroids are of universal occurrence in plants. They have been reported to affect plant growth and development through a spectrum of physiological responses. Recently they are reported to confer resistance in plants against a number of biotic and abiotic stresses. In the present study, a brassinosteroid was isolated from Aegle marmelos Correa. (Rutaceae) which was characterized to be 24-epibrassinolide (EBL) using various spectroscopic techniques (TLC and ESI-MS analysis). It was evaluated for the antigenotoxicity against maleic hydrazide (MH) induced genotoxicity in Allium cepa chromosomal aberration assay. It was shown that the percentage of chromosomal aberrations induced by maleic hydrazide (0.01%) declined significantly with 24-epibrassinolide treatment. EBL (10(-7) M) proved to be the most effective concentration with 91.8% inhibition. This is the first report on the isolation of 24-epibrassinolide from Aegle marmelos and its antigenotoxic effects against MH employing Allium cepa chromosomal aberration assay.
 
Publisher Springer, Van Godewijckstraat 30, 3311 GZ Dordrecht, Netherlands
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/310/1/303_2008_Isolation.pdf
Sondhi, N and Bhardwaj, R and Kaur, S and Kumar, Neeraj and Singh , Bikram (2008) Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay. Plant Growth Regulation , 54 (3). pp. 217-224. ISSN 0167-6903
 
Relation http://ihbt.csircentral.net/310/